Extrusion system offers maximum process flexibility
With a maximum throughput rate of 10 kg/h, the ZSK 18 MEGAlab is suitable for both wet extrusion and hot melt extrusion (HME) on a laboratory scale. For wet extrusion processes the system comprises more than ten different die plates with various numbers of die holes and die hole diameters. For hot melt extrusion applications Coperion has equipped the ZSK extruder with a die head that has several exchangeable nozzles to provide different strand diameters. The die head offers additional bore holes for PAT (Process Analytical Technology) sensors.
The Coperion K-Tron liquid gravimetric loss-in-weight feeder fulfills ATEX requirements and can be connected to each of the barrels of the extruder process section. This flexibility in feeding also applies to the Coperion K-Tron API gravimetric loss-in-weight feeder. It can be mounted on the first barrel or fourth barrel of the process section. This allows the use of the ZSK extruder for processes requiring process lengths of 32 L/D as well as of 20 L/D.
The Coperion K-Tron gravimetric feeders also offer flexibility in their ability to handle a wide variety of materials - even those with difficult flow characteristics - as well as variable feed rates. This flexibility, coupled with Coperion K-Tron’s superior digital weighing and controls technology, ensures high accuracies in materials feeding, all critical to the continuous pharmaceutical process.
The ZSK extruder itself and all peripheral equipment are very compact in size and are movable on wheels for optimal usage in laboratory conditions. The GAMP control system, as well as the water cooling manifold, is integrated into the stainless steel base frame of the ZSK extruder. Thanks to plug & play connections commissioning is possible in the shortest times.
Due to geometrical consistency within the ZSK series the ZSK 18 MEGAlab system allows proven scale-up to larger ZSK extruder sizes and higher throughput rates. This is one of the most important requirements for successful laboratory installation.
Stefan Gebhardt, General Manager of Business Unit Food & Pharma at Coperion, says: “We have designed an extrusion system that optimally meets two very important requirements of the pharma industry. The system offers a large number of features for various application processes and at the same time fulfills all state-of-the-art GMP requirements. This way the ZSK extrusion system can be used with maximum flexibility – for a wide range of research and development tasks as well as for clinical trials and small-scale production processes.”